IL-10, Interleukin-10, human

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IL-10, Interleukin-10, human

Cat.#: RC212-21

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Size:
RC212-21 (2ug)
RC212-21 (10ug)
RC212-21 (1mg)

Quantity:

DG: No

Storage: (-15 to -20)C

Sterile: Yes

Stock: Inquire

$155.92

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$155.92

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Product Description: IL-10, Interleukin-10, human: Interleukin 10, also known as cytokine synthesis inhibitory factor (CSIF), is the charter member of the IL-10 family of α-helical cytokines that also includes IL-19, IL-20, IL-22, IL-24, and IL-26/AK155 . IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts . Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells . IL10 is a 178 amino acid molecule that contains two intrachain disulfide bridges and is expressed as a 36 kDa noncovalently associated homodimer . The IL-10 dimer binds to two IL-10 Rα/IL-10R1 chains, resulting in recruitment of two IL-10 Rβ/IL-10R2 chains and activation of a signaling cascade involving JAK1, TYK2, and STAT3 . IL-10Rβ does not bind IL-10 by itself but is required for signal transduction . IL-10 is a critical molecule in the control of viral infections and allergic and autoimmune inflammation. It promotes phagocytic uptake and Th2 responses but suppresses antigen presentation and Th1 proinflammatory responses. , Accession number: NM_000572, UnitProt ID: P22301

Total Product Size:
RC212-21 (2ug)
RC212-21 (10ug)
RC212-21 (1mg)

Number of Containers: 1

Refrigeration Requirements: Freezer

Shipping Conditions: ICE

UNSPSC Code: 41116127

UNSPSC Category: Other Cytokines and Chemokines

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