Home / Services / Oligo Synthesis / Modifications

Our Oligo Synthesis Services

Our Oligo Modifications

We at Bio Basic have modified our oligo synthesis process to allow a simpler and more consistent approach to this pricing structure and final yield deliverable. Because of this we guarantee the total yield of each oligonucleotide as a FIXED final yield in OD units.

Synthesis of modified oligos is one of our key specialties, and is also one of the most affordable premium services in the market. Our modified oligos are all HPLC purified ONLY. Pricing listed below includes HPLC purification (no extra cost).

Cost per modified oligo = Table A (Modifications) + Table B (Synthesis)

i.e. = [selected modification cost at desired final OD] + [standard price/base for HPLC Purified oligo at a given length].

We have many more modifications available than listed in table below. Please inquire at synthesis@biobasic.com. Pricing subject to change without notice.

COVID-19 Coronavirus primers and probes

Table A - Modifications:


Modification (Mod.) Name
5' Mod.
3' Mod.
Internal Mod.
Final Yield
Price/Mod. (USD)
Amino Modifier - NH2 C12 - - 2 ODs $45.00
Amino Modifier - NH2 C12 - - 5 ODs $60.00
Amino Modifier - NH2 C12 - - 10 ODs $90.00
Amino Modifier - NH2 C6 - - 2 ODs $15.00
Amino Modifier - NH2 C6 - - 5 ODs $20.00
Amino Modifier - NH2 C6 - - 10 ODs $30.00
Amino Modifier - NH2 C6 - - 2 ODs $20.00
Amino Modifier - NH2 C6 - - 5 ODs $25.00
Amino Modifier - NH2 C6 - - 10 ODs $40.00
Amino Modifier - NH2 C6 dT - - 2 ODs $50.00
Amino Modifier - NH2 C6 dT - - 5 ODs $70.00
Amino Modifier - NH2 C6 dT - - 10 ODs $110.00
Amino Modifier - NH2 C6 dT - - 2 ODs $50.00
Amino Modifier - NH2 C6 dT - - 5 ODs $70.00
Amino Modifier - NH2 C6 dT - - 10 ODs $110.00
Amino Modifier - NH2 C7 - - 2 ODs $20.00
Amino Modifier - NH2 C7 - - 5 ODs $25.00
Amino Modifier - NH2 C7 - - 10 ODs $40.00
Biotin - - 2 ODs $30.00
Biotin - - 5 ODs $40.00
Biotin - - 10 ODs $60.00
Biotin - - 2 ODs $30.00
Biotin - - 5 ODs $40.00
Biotin - - 10 ODs $60.00
Biotin dT - - 2 ODs $80.00
Biotin dT - - 5 ODs $100.00
Biotin dT - - 10 ODs $150.00
Biotin-TEG - - 2 ODs $45.00
Biotin-TEG - - 5 ODs $60.00
Biotin-TEG - - 10 ODs $90.00
Biotin-TEG - - 2 ODs $30.00
Biotin-TEG - - 5 ODs $40.00
Biotin-TEG - - 10 ODs $60.00
Dual Biotin - - 2 ODs $120.00
Dual Biotin - - 5 ODs $160.00
Dual Biotin - - 10 ODs $240.00
Desthio Biotin-TEG - - 2 ODs $45.00
Desthio Biotin-TEG - - 5 ODs $60.00
Desthio Biotin-TEG - - 10 ODs $90.00
Carboxy Modifier (C00H) - - 2 ODs $50.00
Carboxy Modifier (C00H) - - 5 ODs $65.00
Carboxy Modifier (C00H) - - 10 ODs $100.00
Digoxigenin dT - - 2 ODs $120.00
Digoxigenin dT - - 5 ODs $160.00
Digoxigenin dT - - 10 ODs $240.00
Digoxigenin NHS Ester - - 2 ODs $60.00
Digoxigenin NHS Ester - - 5 ODs $80.00
Digoxigenin NHS Ester - - 10 ODs $120.00
Digoxigenin NHS Ester - - 2 ODs $70.00
Digoxigenin NHS Ester - - 5 ODs $90.00
Digoxigenin NHS Ester - - 10 ODs $135.00
Dithiol - - 2 ODs $120.00
Dithiol - - 5 ODs $160.00
Dithiol - - 10 ODs $240.00
Dithiol - - 2 ODs $120.00
Dithiol - - 5 ODs $160.00
Dithiol - - 10 ODs $240.00
Dithiol - - 2 ODs $120.00
Dithiol - - 5 ODs $160.00
Dithiol - - 10 ODs $240.00
Ferrocene Modifier - - 2 ODs $45.00
Ferrocene Modifier - - 5 ODs $60.00
Ferrocene Modifier - - 10 ODs $90.00
Ferrocene Modifier - - 2 ODs $55.00
Ferrocene Modifier - - 5 ODs $70.00
Ferrocene Modifier - - 10 ODs $105.00
Thiol Modifier C3 SH - - 2 ODs $50.00
Thiol Modifier C3 SH - - 5 ODs $65.00
Thiol Modifier C3 SH - - 10 ODs $100.00
Thiol Modifier C3 S-S - - 2 ODs $45.00
Thiol Modifier C3 S-S - - 5 ODs $60.00
Thiol Modifier C3 S-S - - 10 ODs $90.00
Thiol Modifier C6 SH - - 2 ODs $50.00
Thiol Modifier C6 SH - - 5 ODs $65.00
Thiol Modifier C6 SH - - 10 ODs $100.00
Thiol Modifier C6 SH - - 2 ODs $50.00
Thiol Modifier C6 SH - - 5 ODs $65.00
Thiol Modifier C6 SH - - 10 ODs $100.00
Thiol Modifier C6 S-S - - 2 ODs $45.00
Thiol Modifier C6 S-S - - 5 ODs $60.00
Thiol Modifier C6 S-S - - 10 ODs $90.00
Thiol Modifier C6 S-S - - 2 ODs $45.00
Thiol Modifier C6 S-S - - 5 ODs $60.00
Thiol Modifier C6 S-S - - 10 ODs $90.00
Thiol Modifier C6 S-S - - 2 ODs $45.00
Thiol Modifier C6 S-S - - 5 ODs $60.00
Thiol Modifier C6 S-S - - 10 ODs $90.00
Dabcyl - - 2 ODs $55.00
Dabcyl - - 5 ODs $70.00
Dabcyl - - 10 ODs $105.00
Dabcyl dT - - 2 ODs $105.00
Dabcyl dT - - 5 ODs $140.00
Dabcyl dT - - 10 ODs $215.00
Dabcyl NHS Ester - - 2 ODs $55.00
Dabcyl NHS Ester - - 5 ODs $70.00
Dabcyl NHS Ester - - 10 ODs $105.00
Eclipse - - 2 ODs $55.00
Eclipse - - 5 ODs $70.00
Eclipse - - 10 ODs $105.00
6-FAM - - 2 ODs $30.00
6-FAM - - 5 ODs $40.00
6-FAM - - 10 ODs $60.00
6-FAM - - 2 ODs $30.00
6-FAM - - 5 ODs $40.00
6-FAM - - 10 ODs $60.00
6-FAM dT - - 2 ODs $80.00
6-FAM dT - - 5 ODs $110.00
6-FAM dT - - 10 ODs $170.00
Alexa Fluor 488 - - 2 ODs $90.00
Alexa Fluor 488 - - 5 ODs $135.00
Alexa Fluor 488 - - 10 ODs $200.00
Alexa Fluor 488 - - 2 ODs $90.00
Alexa Fluor 488 - - 5 ODs $135.00
Alexa Fluor 488 - - 10 ODs $200.00
AMCA - - 2 ODs $90.00
AMCA - - 5 ODs $135.00
AMCA - - 10 ODs $200.00
AMCA - - 2 ODs $90.00
AMCA - - 5 ODs $135.00
AMCA - - 10 ODs $200.00
CY3 - - 2 ODs $80.00
CY3 - - 5 ODs $120.00
CY3 - - 10 ODs $180.00
CY3 - - 2 ODs $90.00
CY3 - - 5 ODs $135.00
CY3 - - 10 ODs $200.00
CY3 - - 2 ODs $90.00
CY3 - - 5 ODs $135.00
CY3 - - 10 ODs $200.00
CY5 dT - - 2 ODs $120.00
CY5 dT - - 5 ODs $160.00
CY5 dT - - 10 ODs $240.00
CY5 NHS Ester - - 2 ODs $80.00
CY5 NHS Ester - - 5 ODs $120.00
CY5 NHS Ester - - 10 ODs $180.00
CY5 NHS Ester - - 2 ODs $90.00
CY5 NHS Ester - - 5 ODs $135.00
CY5 NHS Ester - - 10 ODs $200.00
CY5.5 - - 2 ODs $120.00
CY5.5 - - 5 ODs $160.00
CY5.5 - - 10 ODs $240.00
CY5.5 - - 2 ODs $120.00
CY5.5 - - 5 ODs $160.00
CY5.5 - - 10 ODs $240.00
DBCO - - 2 ODs $65.00
DBCO - - 5 ODs $85.00
DBCO - - 10 ODs $130.00
DBCO - - 2 ODs $65.00
DBCO - - 5 ODs $85.00
DBCO - - 10 ODs $130.00
HEX - - 2 ODs $45.00
HEX - - 5 ODs $60.00
HEX - - 10 ODs $90.00
HEX - - 2 ODs $55.00
HEX - - 5 ODs $70.00
HEX - - 10 ODs $105.00
JOE NHS Ester - - 2 ODs $55.00
JOE NHS Ester - - 5 ODs $70.00
JOE NHS Ester - - 10 ODs $105.00
JOE NHS Ester - - 2 ODs $65.00
JOE NHS Ester - - 5 ODs $85.00
JOE NHS Ester - - 10 ODs $130.00
Methylene Blue - - 2 ODs $120.00
Methylene Blue - - 5 ODs $160.00
Methylene Blue - - 10 ODs $240.00
Methylene Blue - - 2 ODs $120.00
Methylene Blue - - 5 ODs $160.00
Methylene Blue - - 10 ODs $240.00
ROX NHS Ester - - 2 ODs $55.00
ROX NHS Ester - - 5 ODs $70.00
ROX NHS Ester - - 10 ODs $105.00
ROX NHS Ester - - 2 ODs $65.00
ROX NHS Ester - - 5 ODs $85.00
ROX NHS Ester - - 10 ODs $130.00
TAMRA dT - - 2 ODs $80.00
TAMRA dT - - 5 ODs $110.00
TAMRA dT - - 10 ODs $170.00
TAMRA NHS Ester - - 2 ODs $45.00
TAMRA NHS Ester - - 5 ODs $60.00
TAMRA NHS Ester - - 10 ODs $90.00
TAMRA NHS Ester - - 2 ODs $55.00
TAMRA NHS Ester - - 5 ODs $70.00
TAMRA NHS Ester - - 10 ODs $105.00
TET - - 2 ODs $45.00
TET - - 5 ODs $60.00
TET - - 10 ODs $90.00
TET - - 2 ODs $55.00
TET - - 5 ODs $70.00
TET - - 10 ODs $105.00
Texas Red - - 2 ODs $55.00
Texas Red - - 5 ODs $70.00
Texas Red - - 10 ODs $105.00
Texas Red - - 2 ODs $65.00
Texas Red - - 5 ODs $85.00
Texas Red - - 10 ODs $130.00
Dideoxy-A (ddC) - - 2 ODs $65.00
Dideoxy-A (ddC) - - 5 ODs $85.00
Dideoxy-A (ddC) - - 10 ODs $130.00
Dideoxy-C (ddC) - - 2 ODs $65.00
Dideoxy-C (ddC) - - 5 ODs $85.00
Dideoxy-C (ddC) - - 10 ODs $130.00
Dideoxy-G (ddC) - - 2 ODs $65.00
Dideoxy-G (ddC) - - 5 ODs $85.00
Dideoxy-G (ddC) - - 10 ODs $130.00
Dideoxy-T (ddC) - - 2 ODs $65.00
Dideoxy-T (ddC) - - 5 ODs $85.00
Dideoxy-T (ddC) - - 10 ODs $130.00
2-Aminopurine - - 2 ODs $45.00
2-Aminopurine - - 5 ODs $60.00
2-Aminopurine - - 10 ODs $90.00
2F-RNA Modifier - - 2 ODs $30.00
2F-RNA Modifier - - 5 ODs $45.00
2F-RNA Modifier - - 10 ODs $70.00
2'-O-Methyl - - 2 ODs $6.00
2'-O-Methyl - - 5 ODs $10.00
2'-O-Methyl - - 10 ODs $14.00
5-Aza-2'-deoxycytidine - - 2 ODs $120.00
5-Aza-2'-deoxycytidine - - 5 ODs $160.00
5-Aza-2'-deoxycytidine - - 10 ODs $240.00
5-Bromo dU - - 2 ODs $45.00
5-Bromo dU - - 5 ODs $60.00
5-Bromo dU - - 10 ODs $90.00
8-OXO-dA - - 2 ODs $120.00
8-OXO-dA - - 5 ODs $160.00
8-OXO-dA - - 10 ODs $240.00
8-OXO-dG - - 2 ODs $120.00
8-OXO-dG - - 5 ODs $160.00
8-OXO-dG - - 10 ODs $240.00
DeoxyInosine dI - - 2 ODs $6.00
DeoxyInosine dI - - 5 ODs $10.00
DeoxyInosine dI - - 10 ODs $14.00
DeoxyUridine dU - - 2 ODs $6.00
DeoxyUridine dU - - 5 ODs $10.00
DeoxyUridine dU - - 10 ODs $14.00
Inverted dA - - 2 ODs $30.00
Inverted dA - - 5 ODs $40.00
Inverted dA - - 10 ODs $60.00
Inverted dC - - 2 ODs $30.00
Inverted dC - - 5 ODs $40.00
Inverted dC - - 10 ODs $60.00
Inverted dG - - 2 ODs $30.00
Inverted dG - - 5 ODs $40.00
Inverted dG - - 10 ODs $60.00
Inverted dT - - 2 ODs $30.00
Inverted dT - - 5 ODs $40.00
Inverted dT - - 10 ODs $60.00
Phosphorothioate Bond - - 2 ODs $6.00
Phosphorothioate Bond - - 5 ODs $10.00
Phosphorothioate Bond - - 10 ODs $14.00
Pyrrolo-dC - - 2 ODs $120.00
Pyrrolo-dC - - 5 ODs $160.00
Pyrrolo-dC - - 10 ODs $240.00
XNA Modifier - backbone mod. - - 2 ODs $30.00
XNA Modifier - backbone mod. - - 5 ODs $45.00
XNA Modifier - backbone mod. - - 10 ODs $70.00
Phosphorylation - - 2 OD $20.00
Phosphorylation - - 5 OD $25.00
Phosphorylation - - 10 OD $40.00
Phosphorylation - - 2 OD $25.00
Phosphorylation - - 5 OD $32.00
Phosphorylation - - 10 OD $48.00
C3 Spacer - - 2 OD $30.00
C3 Spacer - - 5 OD $40.00
C3 Spacer - - 10 OD $60.00
C3 Spacer - - 2 OD $30.00
C3 Spacer - - 5 OD $40.00
C3 Spacer - - 10 OD $60.00
C3 Spacer - - 2 OD $30.00
C3 Spacer - - 5 OD $40.00
C3 Spacer - - 10 OD $60.00
C6 Spacer - - 2 OD $30.00
C6 Spacer - - 5 OD $40.00
C6 Spacer - - 10 OD $60.00
C6 Spacer - - 2 OD $30.00
C6 Spacer - - 5 OD $40.00
C6 Spacer - - 10 OD $60.00
C6 Spacer - - 2 OD $30.00
C6 Spacer - - 5 OD $40.00
C6 Spacer - - 10 OD $60.00
dSpacer - - 2 OD $45.00
dSpacer - - 5 OD $60.00
dSpacer - - 10 OD $90.00
dSpacer - - 2 OD $45.00
dSpacer - - 5 OD $60.00
dSpacer - - 10 OD $90.00
dSpacer - - 2 OD $45.00
dSpacer - - 5 OD $60.00
dSpacer - - 10 OD $90.00
PC Linker - - 2 OD $120.00
PC Linker - - 5 OD $160.00
PC Linker - - 10 OD $240.00
PC Linker - - 2 OD $120.00
PC Linker - - 5 OD $160.00
PC Linker - - 10 OD $240.00
PC Linker - - 2 OD $120.00
PC Linker - - 5 OD $160.00
PC Linker - - 10 OD $240.00
Spacer 18 - - 2 OD $45.00
Spacer 18 - - 5 OD $60.00
Spacer 18 - - 10 OD $90.00
Spacer 18 - - 2 OD $45.00
Spacer 18 - - 5 OD $60.00
Spacer 18 - - 10 OD $90.00
Spacer 18 - - 2 OD $45.00
Spacer 18 - - 5 OD $60.00
Spacer 18 - - 10 OD $90.00
Spacer 9 - - 2 OD $45.00
Spacer 9 - - 5 OD $60.00
Spacer 9 - - 10 OD $90.00
Spacer 9 - - 2 OD $45.00
Spacer 9 - - 5 OD $60.00
Spacer 9 - - 10 OD $90.00
Spacer 9 - - 2 OD $45.00
Spacer 9 - - 5 OD $60.00
Spacer 9 - - 10 OD $90.00
6-FAM & Eclipse 6-FAM Eclipse - 2 OD $90.00
6-FAM & Eclipse 6-FAM Eclipse - 5 OD $120.00
6-FAM & Eclipse 6-FAM Eclipse - 10 OD $150.00
6-FAM & TAMRA NHS Ester 6-FAM TAMRA NHS Ester - 2 OD $90.00
6-FAM & TAMRA NHS Ester 6-FAM TAMRA NHS Ester - 5 OD $120.00
6-FAM & TAMRA NHS Ester 6-FAM TAMRA NHS Ester - 10 OD $150.00
HEX & Eclipse HEX Eclipse - 2 OD $120.00
HEX & Eclipse HEX Eclipse - 5 OD $160.00
HEX & Eclipse HEX Eclipse - 10 OD $200.00
HEX & TAMRA NHS Ester HEX TAMRA NHS Ester - 2 OD $120.00
HEX & TAMRA NHS Ester HEX TAMRA NHS Ester - 5 OD $160.00
HEX & TAMRA NHS Ester HEX TAMRA NHS Ester - 10 OD $200.00
ROX NHS Ester & Eclipse ROX NHS Ester Eclipse - 2 OD $120.00
ROX NHS Ester & Eclipse ROX NHS Ester Eclipse - 5 OD $160.00
ROX NHS Ester & Eclipse ROX NHS Ester Eclipse - 10 OD $200.00
TET & TAMRA NHS Ester TET TAMRA NHS Ester - 2 OD $120.00
TET & TAMRA NHS Ester TET TAMRA NHS Ester - 5 OD $160.00
TET & TAMRA NHS Ester TET TAMRA NHS Ester - 10 OD $200.00
6-FAM & Dabcyl 6-FAM Dabcyl - 2 OD $90.00
6-FAM & Dabcyl 6-FAM Dabcyl - 5 OD $120.00
6-FAM & Dabcyl 6-FAM Dabcyl - 10 OD $150.00
CY3 & Dabcyl CY3 Dabcyl - 2 OD $150.00
CY3 & Dabcyl CY3 Dabcyl - 5 OD $225.00
CY3 & Dabcyl CY3 Dabcyl - 10 OD $280.00
CY5 & Dabcyl CY5 Dabcyl - 2 OD $150.00
CY5 & Dabcyl CY5 Dabcyl - 5 OD $225.00
CY5 & Dabcyl CY5 Dabcyl - 10 OD $280.00
HEX & Dabcyl HEX Dabcyl - 2 OD $120.00
HEX & Dabcyl HEX Dabcyl - 5 OD $160.00
HEX & Dabcyl HEX Dabcyl - 10 OD $200.00
JOE & Dabcyl JOE Dabcyl - 2 OD $120.00
JOE & Dabcyl JOE Dabcyl - 5 OD $160.00
JOE & Dabcyl JOE Dabcyl - 10 OD $200.00
ROX & Dabcyl ROX Dabcyl - 2 OD $120.00
ROX & Dabcyl ROX Dabcyl - 5 OD $160.00
ROX & Dabcyl ROX Dabcyl - 10 OD $200.00
TAMRA NHS Ester & Dabcyl TAMRA NHS Ester Dabcyl - 2 OD $120.00
TAMRA NHS Ester & Dabcyl TAMRA NHS Ester Dabcyl - 5 OD $160.00
TAMRA NHS Ester & Dabcyl TAMRA NHS Ester Dabcyl - 10 OD $200.00
TET & Dabcyl TET Dabcyl - 2 OD $120.00
TET & Dabcyl TET Dabcyl - 5 OD $160.00
TET & Dabcyl TET Dabcyl - 10 OD $200.00
Texas Red & Dabcyl Texas Red Dabcyl - 2 OD $150.00
Texas Red & Dabcyl Texas Red Dabcyl - 5 OD $225.00
Texas Red & Dabcyl Texas Red Dabcyl - 10 OD $280.00

Table B - Synthesis:

Purification
Type
 Final Yield (based on oligo length) Pricing
5-59 bases 11-59 bases 60-99 bases 100-130 bases per base (USD) per oligo (USD)**
HPLC
(>85% Pure*)
Short oligo
 2 OD - - - $0.20 -
5 OD - 2 OD - $0.35 -
10 OD - 5 OD 2 OD $0.55 -
HPLC-CE
(>85% Pure**)
Guaranteed
 - 2 OD - - $0.20 $12.00
- 5 OD - - $0.35 $16.00
- 10 OD - - $0.55 $20.00

* = Based on an oligo length of 30 bases.

** = An additional purification cost per oligo for HPLC (non-modified) and HPLC-CE purified oligos.

Remember that the synthesis scale (25 nmol, 100 nmol etc.), refers to the STARTING MATERIAL for oligo synthesis, and NOT the FINAL yield. Oligo length, sequence, GC content and coupling efficiencies alter the final nmol yield. Different purification methods alter the final yield as well. Bio Basic guarantees the final yield of each oligo nucleotide as a fixed yield in OD units.

SAVE with our Bimonthly newsletter

opt-out anytime
Contact us
Products
Services
Promotions
Company
Follow Us




20 Konrad Crescent, Markham ON, Canada, L3R 8T4 | 4160 Bailey Avenue, Amherst, NY, USA, 14226 | Copyright © 2017 Bio Basic Inc. All rights reserved