UBC12, Ubiquitin Conjugating Enzyme 12 (His6-tagged), human

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UBC12, Ubiquitin Conjugating Enzyme 12 (His6-tagged), human

Cat.#: RC612-23

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DG: No

Storage: (-15 to -20)C

Sterile: Yes

Stock: Inquire

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Product Description: UBC12, Ubiquitin Conjugating Enzyme 12 (His6-tagged), human: NEDD8-Conjugating Enzyme Ubc12 belongs to the ubiquitin-conjugating enzyme family and is encoded by the UBE2M gene in humans. The ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, take part in the second step in the ubiquitination reaction. In this reaction, E1 activates the ubiquitin by covalently attaching the molecule to its active site cysteine residue. The activated ubiquitin is then transferred to an E2 cysteine and then the E2 molecule binds E3 via a structurally conserved binding region. The UBC12 accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Additionally, it involved in cell proliferation.

Number of Containers: 1

Refrigeration Requirements: Freezer

Shipping Conditions: ICE

UNSPSC Code: 12352202

UNSPSC Category: Other Proteins

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