Interleukin-2 (murine)

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IL-2, Interleukin-2, murine (mouse)

Cat.#: RC232-13

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Size:
RC232-13 (5ug)
RC232-13 (20ug)
RC232-13 (1mg)

Quantity:

DG: No

Storage: (-15 to -20)C

Sterile: Yes

Stock: Inquire

US$64.43

*size

US$64.43

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Product Description: IL-2, Interleukin-2, murine (mouse): Mature mouse IL-2 shares 56% and 73% aa sequence identity with human and rat IL-2, respectively. It shows strain-specific heterogeneity in an N-terminal region that contains a poly-glutamine stretch. Mouse and human IL-2 exhibit cross-species activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. The 55 kDa IL-2 Rαis specific for IL-2 and binds with low affinity. The 75 kDa IL-2 Rβ, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. The 64 kDa common gamma chainγc/IL-2 Rγ, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 Rβandγc. It drives resting T cells to proliferate and induces IL-2 and IL-2 Rαsynthesis. It contributes to T cell homeostasis by promoting the Fas-induced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes. IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells., UnitProt ID: P04351

Total Product Size:
RC232-13 (5ug)
RC232-13 (20ug)
RC232-13 (1mg)

Number of Containers: 1

Refrigeration Requirements: Freezer

Shipping Conditions: ICE

UNSPSC Code: 41116127

UNSPSC Category: Other Cytokines and Chemokines

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