SDF-1 beta, CXCL12 (murine)

Home / SDF-1 beta, CXCL12, murine (mouse)

SDF-1 beta, CXCL12, murine (mouse)

Cat.#: RC332-23B

More Views

Size:
RC332-23B (2ug)
RC332-23B (10ug)
RC332-23B (1mg)

Quantity:

DG: No

Storage: (-15 to -20)C

Sterile: Yes

Stock: Inquire

US$128.86

*size

US$128.86

Add Favourite

Unsure about this product? Request a Free Sample* at: order@biobasic.com

More Info

Product Description: SDF-1 beta, CXCL12, murine (mouse): SDF-1α and SDF-1β, members of the chemokine α subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were subsequently also cloned from a human stromal cell line as cytokines that supported the proliferation of a stromal cell-dependent pre-B-cell line. SDF-1α and SDF-1β cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. Both SDF-1α and SDF-1β are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1β and absent from SDF-1α. SDF-1/PBSF is highly conserved between species, with only one amino acid substitution between the mature human and mouse proteins. SDF-1/PBSF acts via the chemokine receptor CXCR4 and has been shown to be a chemoattractant for T-lymphocytes, monocytes, pro- and pre- B cells, but not neutrophils. Mice lacking SDF-1 or CXCR4 have been found to have impaired B-lymphopoiesis, myelopoiesis, vascular development, cardiogenesis and abnormal neuronal cell migration and patterning in the central nervous system ., UnitProt ID: P40224

Total Product Size:
RC332-23B (2ug)
RC332-23B (10ug)
RC332-23B (1mg)

Number of Containers: 1

Refrigeration Requirements: Freezer

Shipping Conditions: ICE

UNSPSC Code: 41116127

UNSPSC Category: Other Cytokines and Chemokines

Documents