Want to Save Your Research Time and Effort? Outsource Your Cloning and DNA Fragment Needs to Us

Gene synthesis, a common practice of synthetic biology, includes a variety of methods to construct and assemble genes from nucleotides de novo. This process is also known as artificial gene synthesis. Contrasting DNA synthesis in living cells, it does not need template DNA. It allows any DNA sequence to be synthesized in the lab.

The synthesis process contains two key steps. The first of which is called solid-phase DNA synthesis. It is sometimes also known as DNA printing, producing oligonucleotide fragments (typically under 200 base pairs). The next step includes connecting the oligonucleotide fragments by capitalizing on different DNA assembly methods. Since artificial gene synthesis does not require template DNA, making an utterly synthetic DNA molecule is theoretically possible with zero limitations on the nucleotide size or sequence.

Gene synthesis is a highly effective and handy solution for scientists and researchers who want to avoid in-house cloning steps and jump directly to practical studies with fully sequence-verified clonal DNA. Here comes another important question – where should researchers and scientists look for custom gene synthesis services? The rest of this post aims to answer that.

Bio Basic, the leading gene manufacturer, is helping researchers to meet their molecular biology needs without compromising on quality. We have 15+ years of experience in this field. So far, we have synthesized millions of base pairs of genes as a silent OEM for biologists and molecular scientists across the globe. We can also do the same for you. From small custom projects to large-scale operations, you can opt for Bio Basic, irrespective of your requirements.

Our gene synthesis cost is highly economical. However, we don’t compromise with quality in order to make our service affordable. In fact, our reputation as gene synthesis experts is only getting increasingly emphasized as other players from this field have failed to deliver large and complex genes. On the other hand, we have more than a 95% completion rate even when constructing and assembling complex gene sequences.

Most gene synthesis service providers rely on silicon well-based platforms. It limits the construction of genes to small and simple ones. Therefore, they fail to assist in significant parts of challenging gene projects. However, our years of experience in this field helped us to crack this mystery. Even though we use inexpensive technology, our team has successfully developed proprietary enzymes and reagents and figured out the best way to utilize them for production without following substandard synthesis practices.

Along with gene synthesis cloning, we also offer several other services, including oligo-synthesis, DNA sequencing, protein production, antibody production, etc. Get in touch with us to learn more about Bio Basic and our comprehensive solutions. Let our team construct custom DNA with 100% sequence accuracy and help you meet your specific research needs.

Visit us at MEDICA 2023.

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Impacts of Automation on DNA Synthesis: A Brief Guide Explained

Recent studies show that the field of synthetic biology has achieved incredible progress with the advancement of technology, for instance, the generation of synthetic RNA and DNA synthesis. All thanks to Automation! The implementation of the automation process in high-throughput DNA synthesis services has made ambitious research projects, like DNA sequencing and drug discoveries, easier than ever!

If you wonder whether automation has any impact in terms of DND synthesis, today’s blog is for you. Let’s get started.

How Is the Automation Process Improving DNA Synthesis Services?

Synthetic biology involves three-part cycles, including design, build, and test, enabling the genome to recognize key molecules and their functions, while driving the modern innovations, whether it be next-generation cell therapies or therapeutic antibody developments. Now, the progress depends on the tools, making the workflows more efficient, where automation comes into play!

Automation allows synthetic biology to keep pace with different technologies, such as RNA and DNA synthesis, rapid DNA sequencing, biophysical screening, and much more. Moreover, it accelerates the testing and design of the sequences, ensuring to meet the demand in biotechnology and pharmaceutical research. Otherwise, the turnaround times can be too long for complex projects, in particular.

That’s why different pharmaceutical and biotechnology researchers are eliminating the implementation of synthetic biology bottlenecks in research, especially DNA synthesis and DNA sequencing services, and embracing automated synthetic biology platforms to welcome the new age of discovery. For example:

Antibody discovery

According to recent studies, antibody-based therapeutic generations in the past identified simple targets, whereas new drug candidates nowadays target more complex ones, such as ion channels and G protein-coupled receptors. Any of such discoveries start with DNA sequencing and end with screening, which are proven to be highly efficient procedures. With traditional DNA synthesis, it may take months due to complex antibody sequencing, whether new drug candidates are synthesized and cloned every time.

But, when there are challenging timelines, automated benchtops in DNA synthesis can save your day by supporting high-throughputs seamlessly during the workflows. Also, it helps researchers determine proprietary vector details to remain safe during the discovery process. Yet, they have adopted automated benchtop systems in high-throughput DNA synthesis processes to drive the success rates of antibody discovery. It takes just a few days to build, clone, and amplify new drug candidates.

Immunotherapy discovery

The application of synthetic biology has also been seen in immunotherapy treatments to streamline the process, such as optimizing and screening chimeric antigen receptors (CARs) and T-cell receptors (TCRs). However, the overall workflows used in CAR T-cell therapies can be slowed down by traditional DNA synthesis services as they take a long turnaround time. Implementing automated high-throughput benchtops will accelerate the discovery of TCR and CAR workflows for researchers.

Technical limitations

In terms of drug discovery and development processes during biotechnology and pharmaceutical research, researchers rely on synthetic biology these days. But, since the sequences are complex, lead times for traditional DNA synthesis become more challenging, especially in the case of high-throughput discovery research. Yet, the workflows get slowed down and delayed, which is untenable when it comes to bringing new treatments to the market quickly.

That’s why researchers turn to automated synthetic biology platforms for DNA synthesis services to ensure dozens of production overnight if required. Moreover, it ensures error-correction capabilities, making it easier for researchers to generate highly accurate DNA products

In Conclusion

Rather than in-house, outsourcing DNA synthesis service mitigates costs and cuts the chances of inconsistencies in accuracy and delays during complex workflows with the use of automation. And, if you are looking for a reliable DNA Sequencing provider, count on us. At Bio Basic, we offer efficient and fast DNA sequencing services using automated benchtops and DNA extraction kits at affordable charges to lower costs and cut turnaround times.

Request a quotation now or place an order via email at sequencing@biobasic.com today!