Human MHC Class I Polypeptide-Related Sequence A

Product Description: MIC-A (MHC class I chain-related gene A) is a single-pass type I member protein. It is expressed on the cell
surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and
monocytes. Additionally, MIC-A can be induced by bacterial and viral infections. It shares 85 % amino acid
identity with MIC-B and they are distantly related to the MHC class I proteins. Because they possess three
extracellular Ig-like domains, but unlike classical MHC class I molecules. They do not form a heterodimer with
beta2 microglobulin, but bind as a monomer to a KLRK1/NKG2D that is an activating receptor expressed on NK
cells, NKT cells, γδ T cells, and CD8+ αβ T cells. Recognition of MICA by NKG2D results in the activation of
cytolytic activity and/or cytokine production by these effector cells. MIC-A recognition plays an important role
in tumor surveillance, viral infections, and autoimmune diseases.

Number of Containers: 1

Refrigeration Requirements: Freezer

Shipping Conditions: ICE

UNSPSC Category: Other Proteins

Human MHC Class I Polypeptide-Related Sequence A

Cat.#: RC712-12H

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