To supplement our peptide synthesis service, Bio Basic offers a guaranteed TFA removal service (of < 1% TFA content) for peptides if required.
Trifluoroacetic acid (TFA) is typically used in peptide synthesis during the process of cleaving peptides from their respective resin, as well as an ion pairing agent in HPLC purifications. Therefore synthesized peptides are usually in the form of TFA salts (up to 45% TFA content).
When TFA-salt containing peptides are used in cellular assays, these TFA-salts can be quite problematic as they are known to cause interferences with the resulting experiment, thereby causing significant discrepancies in data.
Price: Varies with peptide synthesis.
Turnaround: Varies with project.