Our Oligo Synthesis Services

Our Experience

For over 15 years, Bio Basic has been synthesizing oligonucleotides for a variety of research applications. Our facilities are especially designed for large volume custom production, incorporating automation to ensure consistent production.

Purification methods include Desalted Purification, High Affinity Purification (HAP - our patented, novel purification method for custom oligos), PAGE, HPLC and HPLC-CE Purification.

Bio Basic also specializes in modified oligonucleotides with a diverse range of modifications available, including Linkers, Spacers, Quenchers, Fluorophores, Modified Bases, Phosphorylation, Probes and many more.

Our oligos are not only of the highest standard, but also the most affordable in the industry, especially for high purity and modifed oligos. This is because we manufacture the majority of our reagents and tools in-house.

To request a quotation or for placing orders, please download our order form (preferred) and email it to our oligo synthesis department at synthesis@biobasic.com. Alternatively, you can email us your sequences directly (including purification type, yield, modifications etc.). Our department will get back to you within 24 hours (on a business day; EST).

Our Pricing and Yield Advantage

Whenever you look for oligonucleotides, you often notice their pricing structure is based on a “scale” or “starting scale” in “nmol” quantity. This can be quite misleading as this actually refers to the quantity ofstarting material” required to synthesize the oligo and gives you no idea about the final yield of oligo you will be receiving.

(This is like going to a bakery where they ask you to pay for your cake based on the quantity of flower, sugar, etc. they will use, and not the final size of the cake).

In addition, based on the oligo facility and methodology(s) used there, the final yield can vary based on the starting material, with some facilities synthesizing higher yields, while others synthesize lower yields, or even mixed yields. In many cases, the final yields are usually not standardized and therefore inconsistent.

We at Bio Basic have modified our oligo synthesis process to allow a simpler and more consistent approach to this pricing structure and final yield deliverable. Because of this we guarantee the total yield of each oligonucleotide as a FIXED final yield in OD (Optical Density) units.

Why work with us?

  • Affordability

    We offer the lowest prices in the industry, especially for high purity and modified oligos:

    • No extra charge for PAGE purifications. Other facilities often have an additional purification charge on top of the price per base.
    • We only charge from $6.00/oligo for HPLC purifications (no hidden extra costs).Others facilities can charge over $50.00/oligo!
    • The modified oligos already include the HPLC purification pricing - so no “surprise” quotations.
    • Price Guarantee - We will beat any competitor's price for identical products or services offered by Bio Basic by up to 10%.
  • Wide range of Modifications

    A wide range of modifications are available for our oligo synthesis. Please inquire as some modification names may be proprietary, therefore we may have alternate names under our listings.

  • Guaranteed Yield Packages

    Unlike other facilities, our oligo deliverables are in a fixed final yield, and measured in OD to allow consistent calculations, as well as allowing us to perform thorough investigations, should an error occur in our process.

Ordering & Quote Estimates

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